Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.
Identifieur interne : 000958 ( Main/Exploration ); précédent : 000957; suivant : 000959Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.
Auteurs : Martin J. Van Den Bent [Pays-Bas] ; Brigitta Baumert [Allemagne] ; Sara C. Erridge [Royaume-Uni] ; Michael A. Vogelbaum [États-Unis] ; Anna K. Nowak [Australie] ; Marc Sanson [France] ; Alba Ariela Brandes [Italie] ; Paul M. Clement [Belgique] ; Jean Francais Baurain [Belgique] ; Warren P. Mason [Canada] ; Helen Wheeler [Australie] ; Olivier L. Chinot [France] ; Sanjeev Gill [Australie] ; Matthew Griffin [Royaume-Uni] ; David G. Brachman [États-Unis] ; Walter Taal [Pays-Bas] ; Roberta Rudà [Italie] ; Michael Weller [Suisse] ; Catherine Mcbain [Royaume-Uni] ; Jaap Reijneveld [Pays-Bas] ; Roelien H. Enting [Pays-Bas] ; Damien C. Weber [Suisse] ; Thierry Lesimple [France] ; Susan Clenton [Royaume-Uni] ; Anja Gijtenbeek [Pays-Bas] ; Sarah Pascoe [Royaume-Uni] ; Ulrich Herrlinger [Allemagne] ; Peter Hau [Allemagne] ; Frederic Dhermain [France] ; Irene Van Heuvel [Pays-Bas] ; Roger Stupp [Suisse] ; Ken Aldape [Canada] ; Robert B. Jenkins [États-Unis] ; Hendrikus Jan Dubbink [Pays-Bas] ; Winand N M. Dinjens [Pays-Bas] ; Pieter Wesseling [Pays-Bas] ; Sarah Nuyens [Belgique] ; Vassilis Golfinopoulos [Belgique] ; Thierry Gorlia [Belgique] ; Wolfgang Wick [Allemagne] ; Johan M. Kros [Pays-Bas]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
The role of temozolomide chemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear. We assessed the use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.
DOI: 10.1016/S0140-6736(17)31442-3
PubMed: 28801186
Affiliations:
- Allemagne, Australie, Belgique, Canada, France, Italie, Pays-Bas, Royaume-Uni, Suisse, États-Unis
- Angleterre, Arizona, Bade-Wurtemberg, Basse-Saxe, District de Cologne, District de Karlsruhe, Grand Manchester, Groningue (province), Gueldre, Hollande-Méridionale, Hollande-Septentrionale, Minnesota, Nouvelle-Galles du Sud, Ohio, Ontario, Piémont, Provence-Alpes-Côte d'Azur, Rhénanie-du-Nord-Westphalie, Région Bretagne, Région de Bruxelles-Capitale, Écosse, Île-de-France
- Amsterdam, Bonn, Bruxelles, Groningue, Groningue (ville), Heidelberg, Manchester, Marseille, Nimègue, Osnabrück, Paris, Rennes, Rotterdam, Sydney, Toronto, Turin, Édimbourg
- Université d'Édimbourg, Université de Groningue, Université de Sydney, Université de Toronto
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.</title><author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands. Electronic address: m.vandenbent@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Baumert, Brigitta" sort="Baumert, Brigitta" uniqKey="Baumert B" first="Brigitta" last="Baumert">Brigitta Baumert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Osnabrück</settlement></placeName></affiliation></author><author><name sortKey="Erridge, Sara C" sort="Erridge, Sara C" uniqKey="Erridge S" first="Sara C" last="Erridge">Sara C. Erridge</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Vogelbaum, Michael A" sort="Vogelbaum, Michael A" uniqKey="Vogelbaum M" first="Michael A" last="Vogelbaum">Michael A. Vogelbaum</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Nowak, Anna K" sort="Nowak, Anna K" uniqKey="Nowak A" first="Anna K" last="Nowak">Anna K. Nowak</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Brandes, Alba Ariela" sort="Brandes, Alba Ariela" uniqKey="Brandes A" first="Alba Ariela" last="Brandes">Alba Ariela Brandes</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Baurain, Jean Francais" sort="Baurain, Jean Francais" uniqKey="Baurain J" first="Jean Francais" last="Baurain">Jean Francais Baurain</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name><affiliation wicri:level="4"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wheeler, Helen" sort="Wheeler, Helen" uniqKey="Wheeler H" first="Helen" last="Wheeler">Helen Wheeler</name><affiliation wicri:level="4"><nlm:affiliation>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Chinot, Olivier L" sort="Chinot, Olivier L" uniqKey="Chinot O" first="Olivier L" last="Chinot">Olivier L. Chinot</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Gill, Sanjeev" sort="Gill, Sanjeev" uniqKey="Gill S" first="Sanjeev" last="Gill">Sanjeev Gill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Griffin, Matthew" sort="Griffin, Matthew" uniqKey="Griffin M" first="Matthew" last="Griffin">Matthew Griffin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Brachman, David G" sort="Brachman, David G" uniqKey="Brachman D" first="David G" last="Brachman">David G. Brachman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Taal, Walter" sort="Taal, Walter" uniqKey="Taal W" first="Walter" last="Taal">Walter Taal</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ruda, Roberta" sort="Ruda, Roberta" uniqKey="Ruda R" first="Roberta" last="Rudà">Roberta Rudà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Mcbain, Catherine" sort="Mcbain, Catherine" uniqKey="Mcbain C" first="Catherine" last="Mcbain">Catherine Mcbain</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Reijneveld, Jaap" sort="Reijneveld, Jaap" uniqKey="Reijneveld J" first="Jaap" last="Reijneveld">Jaap Reijneveld</name><affiliation wicri:level="3"><nlm:affiliation>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Enting, Roelien H" sort="Enting, Roelien H" uniqKey="Enting R" first="Roelien H" last="Enting">Roelien H. Enting</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, UMCG, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, UMCG, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Weber, Damien C" sort="Weber, Damien C" uniqKey="Weber D" first="Damien C" last="Weber">Damien C. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Lesimple, Thierry" sort="Lesimple, Thierry" uniqKey="Lesimple T" first="Thierry" last="Lesimple">Thierry Lesimple</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Clenton, Susan" sort="Clenton, Susan" uniqKey="Clenton S" first="Susan" last="Clenton">Susan Clenton</name><affiliation wicri:level="1"><nlm:affiliation>Weston Park Hospital, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weston Park Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Gijtenbeek, Anja" sort="Gijtenbeek, Anja" uniqKey="Gijtenbeek A" first="Anja" last="Gijtenbeek">Anja Gijtenbeek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Pascoe, Sarah" sort="Pascoe, Sarah" uniqKey="Pascoe S" first="Sarah" last="Pascoe">Sarah Pascoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth</wicri:regionArea><wicri:noRegion>Plymouth</wicri:noRegion></affiliation></author><author><name sortKey="Herrlinger, Ulrich" sort="Herrlinger, Ulrich" uniqKey="Herrlinger U" first="Ulrich" last="Herrlinger">Ulrich Herrlinger</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hau, Peter" sort="Hau, Peter" uniqKey="Hau P" first="Peter" last="Hau">Peter Hau</name><affiliation wicri:level="1"><nlm:affiliation>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Van Heuvel, Irene" sort="Van Heuvel, Irene" uniqKey="Van Heuvel I" first="Irene" last="Van Heuvel">Irene Van Heuvel</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Oncology, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Aldape, Ken" sort="Aldape, Ken" uniqKey="Aldape K" first="Ken" last="Aldape">Ken Aldape</name><affiliation wicri:level="4"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B" last="Jenkins">Robert B. Jenkins</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Dubbink, Hendrikus Jan" sort="Dubbink, Hendrikus Jan" uniqKey="Dubbink H" first="Hendrikus Jan" last="Dubbink">Hendrikus Jan Dubbink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dinjens, Winand N M" sort="Dinjens, Winand N M" uniqKey="Dinjens W" first="Winand N M" last="Dinjens">Winand N M. Dinjens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Nuyens, Sarah" sort="Nuyens, Sarah" uniqKey="Nuyens S" first="Sarah" last="Nuyens">Sarah Nuyens</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Golfinopoulos, Vassilis" sort="Golfinopoulos, Vassilis" uniqKey="Golfinopoulos V" first="Vassilis" last="Golfinopoulos">Vassilis Golfinopoulos</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name><affiliation wicri:level="3"><nlm:affiliation>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:28801186</idno><idno type="pmid">28801186</idno><idno type="doi">10.1016/S0140-6736(17)31442-3</idno><idno type="wicri:Area/PubMed/Corpus">000417</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000417</idno><idno type="wicri:Area/PubMed/Curation">000415</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000415</idno><idno type="wicri:Area/PubMed/Checkpoint">000415</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000415</idno><idno type="wicri:Area/Ncbi/Merge">004C79</idno><idno type="wicri:Area/Ncbi/Curation">004C79</idno><idno type="wicri:Area/Ncbi/Checkpoint">004C79</idno><idno type="wicri:Area/Main/Merge">000953</idno><idno type="wicri:Area/Main/Curation">000958</idno><idno type="wicri:Area/Main/Exploration">000958</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.</title><author><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands. Electronic address: m.vandenbent@erasmusmc.nl.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Baumert, Brigitta" sort="Baumert, Brigitta" uniqKey="Baumert B" first="Brigitta" last="Baumert">Brigitta Baumert</name><affiliation wicri:level="3"><nlm:affiliation>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Radiation-Oncology (MAASTRO), Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; GROW School for Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands; Department of Radiation-Oncology, University of Münster, Münster, Germany; Paracelsus Clinic, Osnabrück</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Osnabrück</settlement></placeName></affiliation></author><author><name sortKey="Erridge, Sara C" sort="Erridge, Sara C" uniqKey="Erridge S" first="Sara C" last="Erridge">Sara C. Erridge</name><affiliation wicri:level="4"><nlm:affiliation>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Edinburgh Centre for Neuro-Oncology, Western General Hospital, University of Edinburgh, Edinburgh</wicri:regionArea><placeName><settlement type="city">Édimbourg</settlement><region type="country">Écosse</region><settlement type="city">Édimbourg</settlement></placeName><orgName type="university">Université d'Édimbourg</orgName></affiliation></author><author><name sortKey="Vogelbaum, Michael A" sort="Vogelbaum, Michael A" uniqKey="Vogelbaum M" first="Michael A" last="Vogelbaum">Michael A. Vogelbaum</name><affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurosurgery, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA; Rose Ella Burkhardt Brain Tumor and Neuro-Oncology Center, Cleveland Clinic, Cleveland, OH</wicri:regionArea><placeName><region type="state">Ohio</region></placeName></affiliation></author><author><name sortKey="Nowak, Anna K" sort="Nowak, Anna K" uniqKey="Nowak A" first="Anna K" last="Nowak">Anna K. Nowak</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>School of Medicine and Pharmacology, University of Western Australia, Crawley, WA, Australia; Co-Operative Group for Neuro-Oncology, University of Sydney, Camperdown, NSW, Australia; Department of Medical Oncology, Sir Charles Gairdner Hospital, Hospital Avenue, Nedlands, WA</wicri:regionArea><wicri:noRegion>WA</wicri:noRegion></affiliation></author><author><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name><affiliation wicri:level="3"><nlm:affiliation>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Sorbonne Universités UPMC, University Paris VI, INSERM, CNRS, APHP, Institut du Cerveau et de la Moelle (ICM), Hôpital Pitié-Salpêtrière, F-75013, Paris</wicri:regionArea><placeName><settlement type="city">Paris</settlement><region type="région" nuts="2">Île-de-France</region></placeName></affiliation></author><author><name sortKey="Brandes, Alba Ariela" sort="Brandes, Alba Ariela" uniqKey="Brandes A" first="Alba Ariela" last="Brandes">Alba Ariela Brandes</name><affiliation wicri:level="1"><nlm:affiliation>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Medical Oncology Department, AUSL-IRCCS Scienze Neurologiche, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of Oncology, KU Leuven, Leuven, Belgium; Department of General Medical Oncology, UZ Leuven, Leuven Cancer Institute, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Baurain, Jean Francais" sort="Baurain, Jean Francais" uniqKey="Baurain J" first="Jean Francais" last="Baurain">Jean Francais Baurain</name><affiliation wicri:level="3"><nlm:affiliation>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Medical Oncology Department, King Albert II Cancer Institute, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name><affiliation wicri:level="4"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Wheeler, Helen" sort="Wheeler, Helen" uniqKey="Wheeler H" first="Helen" last="Wheeler">Helen Wheeler</name><affiliation wicri:level="4"><nlm:affiliation>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Northern Sydney Cancer Centre, North Shore Hospital, St Leonards, NSW, Australia; Department of Medicine, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Chinot, Olivier L" sort="Chinot, Olivier L" uniqKey="Chinot O" first="Olivier L" last="Chinot">Olivier L. Chinot</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Neuro-Oncology Division, Aix-Marseille University, AP-HM, Marseille</wicri:regionArea><placeName><region type="region">Provence-Alpes-Côte d'Azur</region><region type="old region">Provence-Alpes-Côte d'Azur</region><settlement type="city">Marseille</settlement></placeName></affiliation></author><author><name sortKey="Gill, Sanjeev" sort="Gill, Sanjeev" uniqKey="Gill S" first="Sanjeev" last="Gill">Sanjeev Gill</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Medical Oncology, Alfred Hospital, Melbourne, VIC</wicri:regionArea><wicri:noRegion>VIC</wicri:noRegion></affiliation></author><author><name sortKey="Griffin, Matthew" sort="Griffin, Matthew" uniqKey="Griffin M" first="Matthew" last="Griffin">Matthew Griffin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Nottingham University Hospitals NHS Trust, Nottingham</wicri:regionArea><wicri:noRegion>Nottingham</wicri:noRegion></affiliation></author><author><name sortKey="Brachman, David G" sort="Brachman, David G" uniqKey="Brachman D" first="David G" last="Brachman">David G. Brachman</name><affiliation wicri:level="2"><nlm:affiliation>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Radiation Oncology, Barrow Neurological Institute, Phoenix, AZ</wicri:regionArea><placeName><region type="state">Arizona</region></placeName></affiliation></author><author><name sortKey="Taal, Walter" sort="Taal, Walter" uniqKey="Taal W" first="Walter" last="Taal">Walter Taal</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Ruda, Roberta" sort="Ruda, Roberta" uniqKey="Ruda R" first="Roberta" last="Rudà">Roberta Rudà</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neuro-Oncology, City of Health and Science Hospital and University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name><affiliation wicri:level="1"><nlm:affiliation>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Neurology and Brain Tumour Centre, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Mcbain, Catherine" sort="Mcbain, Catherine" uniqKey="Mcbain C" first="Catherine" last="Mcbain">Catherine Mcbain</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Christie NHS Foundation Trust, Manchester</wicri:regionArea><placeName><settlement type="city">Manchester</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Manchester</region></placeName></affiliation></author><author><name sortKey="Reijneveld, Jaap" sort="Reijneveld, Jaap" uniqKey="Reijneveld J" first="Jaap" last="Reijneveld">Jaap Reijneveld</name><affiliation wicri:level="3"><nlm:affiliation>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>VUmc Cancer Centre Amsterdam, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, VU University Medical Centre, Amsterdam, Netherlands; Department of Neurology, Academic Medical Centre, Amsterdam</wicri:regionArea><placeName><settlement type="city">Amsterdam</settlement><region nuts="2" type="province">Hollande-Septentrionale</region></placeName></affiliation></author><author><name sortKey="Enting, Roelien H" sort="Enting, Roelien H" uniqKey="Enting R" first="Roelien H" last="Enting">Roelien H. Enting</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, UMCG, University of Groningen, Groningen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, UMCG, University of Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region><settlement type="city">Groningue (ville)</settlement></placeName><orgName type="university">Université de Groningue</orgName></affiliation></author><author><name sortKey="Weber, Damien C" sort="Weber, Damien C" uniqKey="Weber D" first="Damien C" last="Weber">Damien C. Weber</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Radiation Oncology, University Hospital of Geneva, Geneva</wicri:regionArea><wicri:noRegion>Geneva</wicri:noRegion></affiliation></author><author><name sortKey="Lesimple, Thierry" sort="Lesimple, Thierry" uniqKey="Lesimple T" first="Thierry" last="Lesimple">Thierry Lesimple</name><affiliation wicri:level="3"><nlm:affiliation>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Clinical Oncology, Comprehensive Cancer Center Eugène Marquis, Rennes</wicri:regionArea><placeName><region type="region">Région Bretagne</region><region type="old region">Région Bretagne</region><settlement type="city">Rennes</settlement></placeName></affiliation></author><author><name sortKey="Clenton, Susan" sort="Clenton, Susan" uniqKey="Clenton S" first="Susan" last="Clenton">Susan Clenton</name><affiliation wicri:level="1"><nlm:affiliation>Weston Park Hospital, Sheffield, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Weston Park Hospital, Sheffield</wicri:regionArea><wicri:noRegion>Sheffield</wicri:noRegion></affiliation></author><author><name sortKey="Gijtenbeek, Anja" sort="Gijtenbeek, Anja" uniqKey="Gijtenbeek A" first="Anja" last="Gijtenbeek">Anja Gijtenbeek</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Neurology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Pascoe, Sarah" sort="Pascoe, Sarah" uniqKey="Pascoe S" first="Sarah" last="Pascoe">Sarah Pascoe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Clinical Oncology, Plymouth Hospitals NHS Trust, Plymouth</wicri:regionArea><wicri:noRegion>Plymouth</wicri:noRegion></affiliation></author><author><name sortKey="Herrlinger, Ulrich" sort="Herrlinger, Ulrich" uniqKey="Herrlinger U" first="Ulrich" last="Herrlinger">Ulrich Herrlinger</name><affiliation wicri:level="3"><nlm:affiliation>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Clinical Neuro-Oncology, Department of Neurology, University of Bonn Medical Centre, Bonn</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Bonn</settlement></placeName></affiliation></author><author><name sortKey="Hau, Peter" sort="Hau, Peter" uniqKey="Hau P" first="Peter" last="Hau">Peter Hau</name><affiliation wicri:level="1"><nlm:affiliation>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Wilhelm Sander-Neuro-Oncology Unit and Department of Neurology, University Hospital Regensburg, Regensburg</wicri:regionArea><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion><wicri:noRegion>Regensburg</wicri:noRegion></affiliation></author><author><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name><affiliation wicri:level="1"><nlm:affiliation>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Radiotherapy Department, Gustave Roussy University Hospital, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Van Heuvel, Irene" sort="Van Heuvel, Irene" uniqKey="Van Heuvel I" first="Irene" last="Van Heuvel">Irene Van Heuvel</name><affiliation wicri:level="3"><nlm:affiliation>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Neuro-Oncology Unit, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Oncology, University Hospital and University of Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Medical Oncology, University Hospital and University of Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Aldape, Ken" sort="Aldape, Ken" uniqKey="Aldape K" first="Ken" last="Aldape">Ken Aldape</name><affiliation wicri:level="4"><nlm:affiliation>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Princess Margaret Cancer Centre, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B" last="Jenkins">Robert B. Jenkins</name><affiliation wicri:level="2"><nlm:affiliation>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Dubbink, Hendrikus Jan" sort="Dubbink, Hendrikus Jan" uniqKey="Dubbink H" first="Hendrikus Jan" last="Dubbink">Hendrikus Jan Dubbink</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Dinjens, Winand N M" sort="Dinjens, Winand N M" uniqKey="Dinjens W" first="Winand N M" last="Dinjens">Winand N M. Dinjens</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, VU University Medical Centre, Amsterdam, Netherlands; Department of Pathology, Radboud University Medical Centre, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Nuyens, Sarah" sort="Nuyens, Sarah" uniqKey="Nuyens S" first="Sarah" last="Nuyens">Sarah Nuyens</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Golfinopoulos, Vassilis" sort="Golfinopoulos, Vassilis" uniqKey="Golfinopoulos V" first="Vassilis" last="Golfinopoulos">Vassilis Golfinopoulos</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name><affiliation wicri:level="3"><nlm:affiliation>EORTC, Brussels, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>EORTC, Brussels</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author><author><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name><affiliation wicri:level="3"><nlm:affiliation>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Neurologische Klinik und Nationales Zentrum für Tumorerkrankungen Universitätsklinik, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Pathology, Brain Tumour Centre at Erasmus MC Cancer Institute, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The role of temozolomide chemotherapy in newly diagnosed 1p/19q non-co-deleted anaplastic gliomas, which are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumours, is unclear. We assessed the use of radiotherapy with concurrent and adjuvant temozolomide in adults with non-co-deleted anaplastic gliomas.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Canada</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Arizona</li><li>Bade-Wurtemberg</li><li>Basse-Saxe</li><li>District de Cologne</li><li>District de Karlsruhe</li><li>Grand Manchester</li><li>Groningue (province)</li><li>Gueldre</li><li>Hollande-Méridionale</li><li>Hollande-Septentrionale</li><li>Minnesota</li><li>Nouvelle-Galles du Sud</li><li>Ohio</li><li>Ontario</li><li>Piémont</li><li>Provence-Alpes-Côte d'Azur</li><li>Rhénanie-du-Nord-Westphalie</li><li>Région Bretagne</li><li>Région de Bruxelles-Capitale</li><li>Écosse</li><li>Île-de-France</li></region><settlement><li>Amsterdam</li><li>Bonn</li><li>Bruxelles</li><li>Groningue</li><li>Groningue (ville)</li><li>Heidelberg</li><li>Manchester</li><li>Marseille</li><li>Nimègue</li><li>Osnabrück</li><li>Paris</li><li>Rennes</li><li>Rotterdam</li><li>Sydney</li><li>Toronto</li><li>Turin</li><li>Édimbourg</li></settlement><orgName><li>Université d'Édimbourg</li><li>Université de Groningue</li><li>Université de Sydney</li><li>Université de Toronto</li></orgName></list><tree><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Van Den Bent, Martin J" sort="Van Den Bent, Martin J" uniqKey="Van Den Bent M" first="Martin J" last="Van Den Bent">Martin J. Van Den Bent</name></region><name sortKey="Dinjens, Winand N M" sort="Dinjens, Winand N M" uniqKey="Dinjens W" first="Winand N M" last="Dinjens">Winand N M. Dinjens</name><name sortKey="Dubbink, Hendrikus Jan" sort="Dubbink, Hendrikus Jan" uniqKey="Dubbink H" first="Hendrikus Jan" last="Dubbink">Hendrikus Jan Dubbink</name><name sortKey="Enting, Roelien H" sort="Enting, Roelien H" uniqKey="Enting R" first="Roelien H" last="Enting">Roelien H. Enting</name><name sortKey="Gijtenbeek, Anja" sort="Gijtenbeek, Anja" uniqKey="Gijtenbeek A" first="Anja" last="Gijtenbeek">Anja Gijtenbeek</name><name sortKey="Kros, Johan M" sort="Kros, Johan M" uniqKey="Kros J" first="Johan M" last="Kros">Johan M. Kros</name><name sortKey="Reijneveld, Jaap" sort="Reijneveld, Jaap" uniqKey="Reijneveld J" first="Jaap" last="Reijneveld">Jaap Reijneveld</name><name sortKey="Taal, Walter" sort="Taal, Walter" uniqKey="Taal W" first="Walter" last="Taal">Walter Taal</name><name sortKey="Van Heuvel, Irene" sort="Van Heuvel, Irene" uniqKey="Van Heuvel I" first="Irene" last="Van Heuvel">Irene Van Heuvel</name><name sortKey="Wesseling, Pieter" sort="Wesseling, Pieter" uniqKey="Wesseling P" first="Pieter" last="Wesseling">Pieter Wesseling</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Baumert, Brigitta" sort="Baumert, Brigitta" uniqKey="Baumert B" first="Brigitta" last="Baumert">Brigitta Baumert</name></region><name sortKey="Hau, Peter" sort="Hau, Peter" uniqKey="Hau P" first="Peter" last="Hau">Peter Hau</name><name sortKey="Herrlinger, Ulrich" sort="Herrlinger, Ulrich" uniqKey="Herrlinger U" first="Ulrich" last="Herrlinger">Ulrich Herrlinger</name><name sortKey="Wick, Wolfgang" sort="Wick, Wolfgang" uniqKey="Wick W" first="Wolfgang" last="Wick">Wolfgang Wick</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Erridge, Sara C" sort="Erridge, Sara C" uniqKey="Erridge S" first="Sara C" last="Erridge">Sara C. Erridge</name></region><name sortKey="Clenton, Susan" sort="Clenton, Susan" uniqKey="Clenton S" first="Susan" last="Clenton">Susan Clenton</name><name sortKey="Griffin, Matthew" sort="Griffin, Matthew" uniqKey="Griffin M" first="Matthew" last="Griffin">Matthew Griffin</name><name sortKey="Mcbain, Catherine" sort="Mcbain, Catherine" uniqKey="Mcbain C" first="Catherine" last="Mcbain">Catherine Mcbain</name><name sortKey="Pascoe, Sarah" sort="Pascoe, Sarah" uniqKey="Pascoe S" first="Sarah" last="Pascoe">Sarah Pascoe</name></country><country name="États-Unis"><region name="Ohio"><name sortKey="Vogelbaum, Michael A" sort="Vogelbaum, Michael A" uniqKey="Vogelbaum M" first="Michael A" last="Vogelbaum">Michael A. Vogelbaum</name></region><name sortKey="Brachman, David G" sort="Brachman, David G" uniqKey="Brachman D" first="David G" last="Brachman">David G. Brachman</name><name sortKey="Jenkins, Robert B" sort="Jenkins, Robert B" uniqKey="Jenkins R" first="Robert B" last="Jenkins">Robert B. Jenkins</name></country><country name="Australie"><noRegion><name sortKey="Nowak, Anna K" sort="Nowak, Anna K" uniqKey="Nowak A" first="Anna K" last="Nowak">Anna K. Nowak</name></noRegion><name sortKey="Gill, Sanjeev" sort="Gill, Sanjeev" uniqKey="Gill S" first="Sanjeev" last="Gill">Sanjeev Gill</name><name sortKey="Wheeler, Helen" sort="Wheeler, Helen" uniqKey="Wheeler H" first="Helen" last="Wheeler">Helen Wheeler</name></country><country name="France"><region name="Île-de-France"><name sortKey="Sanson, Marc" sort="Sanson, Marc" uniqKey="Sanson M" first="Marc" last="Sanson">Marc Sanson</name></region><name sortKey="Chinot, Olivier L" sort="Chinot, Olivier L" uniqKey="Chinot O" first="Olivier L" last="Chinot">Olivier L. Chinot</name><name sortKey="Dhermain, Frederic" sort="Dhermain, Frederic" uniqKey="Dhermain F" first="Frederic" last="Dhermain">Frederic Dhermain</name><name sortKey="Lesimple, Thierry" sort="Lesimple, Thierry" uniqKey="Lesimple T" first="Thierry" last="Lesimple">Thierry Lesimple</name></country><country name="Italie"><noRegion><name sortKey="Brandes, Alba Ariela" sort="Brandes, Alba Ariela" uniqKey="Brandes A" first="Alba Ariela" last="Brandes">Alba Ariela Brandes</name></noRegion><name sortKey="Ruda, Roberta" sort="Ruda, Roberta" uniqKey="Ruda R" first="Roberta" last="Rudà">Roberta Rudà</name></country><country name="Belgique"><noRegion><name sortKey="Clement, Paul M" sort="Clement, Paul M" uniqKey="Clement P" first="Paul M" last="Clement">Paul M. Clement</name></noRegion><name sortKey="Baurain, Jean Francais" sort="Baurain, Jean Francais" uniqKey="Baurain J" first="Jean Francais" last="Baurain">Jean Francais Baurain</name><name sortKey="Golfinopoulos, Vassilis" sort="Golfinopoulos, Vassilis" uniqKey="Golfinopoulos V" first="Vassilis" last="Golfinopoulos">Vassilis Golfinopoulos</name><name sortKey="Gorlia, Thierry" sort="Gorlia, Thierry" uniqKey="Gorlia T" first="Thierry" last="Gorlia">Thierry Gorlia</name><name sortKey="Nuyens, Sarah" sort="Nuyens, Sarah" uniqKey="Nuyens S" first="Sarah" last="Nuyens">Sarah Nuyens</name></country><country name="Canada"><region name="Ontario"><name sortKey="Mason, Warren P" sort="Mason, Warren P" uniqKey="Mason W" first="Warren P" last="Mason">Warren P. Mason</name></region><name sortKey="Aldape, Ken" sort="Aldape, Ken" uniqKey="Aldape K" first="Ken" last="Aldape">Ken Aldape</name></country><country name="Suisse"><noRegion><name sortKey="Weller, Michael" sort="Weller, Michael" uniqKey="Weller M" first="Michael" last="Weller">Michael Weller</name></noRegion><name sortKey="Stupp, Roger" sort="Stupp, Roger" uniqKey="Stupp R" first="Roger" last="Stupp">Roger Stupp</name><name sortKey="Weber, Damien C" sort="Weber, Damien C" uniqKey="Weber D" first="Damien C" last="Weber">Damien C. Weber</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Interim results from the CATNON trial (EORTC study 26053-22054) of treatment with concurrent and adjuvant temozolomide for 1p/19q non-co-deleted anaplastic glioma: a phase 3, randomised, open-label intergroup study.
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